Fig. 1

Body weight change in the experimental period and silicon accumulation in the liver. Body weight changes in mice treated with 0, 100, 200, or 300 mg of SNPs kg⁻¹ mouse body weight by oral gavage twice per week in the presence of an ND or HFD (a). Each point represents the means ± standard error of the means (n = 6). *, p < 0.05 and **, p < 0.01 when the HFD-SNP0 group was compared with the ND-SNP0 groups using ANOVA. Body weight differences were observed in the ND and HFD mice fed with distinct SNPs (p > 0.05, ANOVA). No significance (n.s.). Silicon accumulation in liver tissue (mg silicon g⁻¹ liver) was measured at 25 weeks by ICP (b). Data are expressed as the means ± standard error of the means (n = 6). #, p < 0.001 when the HFD-SNP300 group was compared with the ND-SNP300 group using ANOVA